Royal Air Force Typhoon jets have conducted a mission with France's air force in a joint strike on an subterranean weapons facility in Syrian territory employed by the IS group, according to the UK Ministry of Defence.
The location, located using intelligence, was believed to be housing weapons and explosive materials, the release indicated, and was positioned in hills just to the north of the ancient city of Palmyra in central Syria.
"Our aircraft employed laser-guided Paveway IV weapons to target a several approach shafts providing entry to the facility... initial indications suggest the strike was effective," officials stated.
There was no sign of any civilian casualties in the attack late on Saturday and all the aircraft made a safe return, the MoD added.
The Typhoon fighters were backed up by a Voyager tanker plane.
The Islamic State group - alternatively referred to as the so-called Islamic State - established jihadist rule over large swathes of both Syria and Iraq until 2019.
"This operation underscores British leadership, and determination to work closely with allied nations, to stamp out any re-emergence of Daesh and their violent and radical beliefs in the area," the British Defence Secretary John Healey said.
British military aircraft have carried out overwatch operations over Syria to "prevent any efforts to regroup" of IS following its defeat at the climactic battle in Baghuz in the year 2019, the ministry said.
"I want to thank the personnel of the UK armed forces involved in this mission for their professionalism and their courage," the Defence Secretary added. "Including them were a great many British personnel on duty over the holidays. This operation, to take out militants who threaten our way of life, highlights how our armed forces are prepared to act, all year round, protecting the UK at home and influential overseas."
During December, the United States armed forces carried out what it described as a "major assault" on Daesh sites in Syria, after an attack resulted in the deaths of two US servicemembers and a civilian linguist in Palmyra.
The UN estimates Islamic State still has roughly 5-7 thousand combatants in Syria and Iraq.